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KMID : 0614020090240010037
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Journal of Pharmaceutical Sciences (C.N.U.)
2009 Volume.24 No. 1 p.37 ~ p.48
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Development and Application of Liposomes for Photodynamic Therapy
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Na Joon-Soo
Park Jeong-Sook
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Abstract
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Photodynamic therapy (PDT) is emerging as a promising approach for the treatment of superficial tumors. PDT technique employes photosensitizing agents that are able to photochemically eradicate malignant cells. Most photosensitizer that are in use clinically or in preclinical development are hydrophobic and tend to aggregate in the aqueous environment, which limits their delivery and photosensitizing efficiency. To overcome or decrease these problems, liposomes are presently being used as carrier and delivery systems for PDT. This review covers the various strategies of liposomal formulations that are available to target photo-sensitizers to tumor tissue. In general, conventional liposomes of photosensitizing agents could not enhance the ratios of tumor-to-normal tissue, hampering their general usages as tumoritropic carriers of photosensitizers. On the other hand, liposomes with a specifically modified design such as PEGylated liposomes or especially actively targeting liposomes, show a better targetability as tumoritropic carriers of photosensitizers. Approaches that can trigger the release of photosensitizer molecules from the liposomes are also summarized.
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KEYWORD
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photodynamic therapy, photosensitizer, conventional liposome, active targeting, passive targeting, triggered release
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